What Happens If You Take Weight Loss Pills Under 18 – A weight loss drug taken by millions of patients over the past two decades has been backed by questionable clinical studies that have “systematically underestimated” the potential harm, according to a new analysis. hidden side of this drug. Danish researchers who reviewed data summaries and published articles found that seven drug trials sponsored by drug manufacturer Roche in the 1990s reduced the frequency of adverse events. Obvious side effects such as diarrhea or urinary incontinence.
The drug, known to scientists as orlistat, and marketed in the United States as Alli, has generated sales in the hundreds of millions but has declined in recent years in part due to its notoriety for its effects. side effects in the gastrointestinal tract.
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Dr Raj Padwal, a clinical pharmacologist and internist at the University of Alberta, said: “The analysis sheds light on ‘something that clinicians often suspect: reporting of adverse events. side effects in clinical trials don’t give the big picture” was not included in the analysis.
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The new study, published Tuesday in the journal PLOS Medicine, did not examine data reports that were submitted to the Food and Drug Administration when orlistat was approved, first in 1999 under prescription drug sold by Roche as Xenical or later as a low dose. , an over-the-counter medication sold by GlaxoSmithKline as Alli. (However, the FDA reviewed data from the trials in question.)
Those trials, conducted in the 1990s by researchers in academic or medical centers, led to papers. To assess the thoroughness of these articles, the Danish researchers compared them with summaries of data submitted to European regulatory authorities, obtained by submitting requests from Freedom of Information Act. They found that the publications revealed only a fraction – between 14 and 33 percent – of the so-called “adverse events” of patients compared with the data summaries.
For example, two of the publications omitted obvious side effects that occurred in less than 5% of trial participants; another counted multiple reports from the same patient as just a side effect.
Two other articles, now listed on Alli’s website as evidence of the drug’s safety and effectiveness, are also problematic. One of them only reported side effects that were apparently considered “common”; Other reports were omitted of apparently uncommon side effects that were at least twice as common in trial participants taking the drug as in those taking placebo.
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Anja von Treskow, a Roche spokeswoman, said that reporting on the tests was “performed according to the standards of the times” and that the company “constantly updates our methods” to comply with these standards. standards they change.
Joanmarie Goddard, a spokeswoman for Alli’s marketer, GlaxoSmithKline, said the company “takes reporting of side effects to our products very seriously and regularly monitors safety information with experts. healthcare – regulatory and healthcare agencies around the world.”
In the first year after Roche brought Xenical to market in the United States, the drug brought in $600 million worldwide. During the 2000s, the drug was prescribed 11 million times in the United States, according to an analysis of data by the consumer group Public Citizen. When GSK launched an over-the-counter drug called Alli in 2007, it was a resounding success, selling $155 million in its first weeks on the market.
This drug, combined with diet and exercise, works by preventing the body from absorbing fat. However, the excretion of a lot of fat makes the stool greasy, leading to many patients experiencing gastrointestinal side effects.
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Even at the top of the pill, the warning signs were visible. US Xenical prescriptions have been decreasing every year. A 2007 study of nearly 17,000 patients found that only 6% of participants were still taking Xenical after one year; after two years, it dropped to 2 percent.
Dr Jeppe Schroll, lead author of the new analysis and a researcher at the Nordic Cochrane Center in Copenhagen, said it was an indication that “the balance between effects and harms is not very favorable”.
Then in 2010, the FDA added a warning to both Xenical and Alli, warning of “rare reports” of liver damage; A 2012 study found toxicity effects so alarming that the researcher immediately reported his findings to the FDA.
Roche no longer markets Xenical in the United States, although generic prescription versions of the drug are still available. GSK no longer analyzes Alli sales in its financial statements and does not comment on current sales figures for this drug. A pack of 120 Alli pills sold online for $56.
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Despite orlistat’s difficulties, the drug’s manufacturers have not given up on the drug. A Canadian pharmaceutical company, M Pharmaceutical, is working on an innovatively formulated alternative that moves away from the socially unacceptable “underwear problem” of existing drugs.
The Danish researchers note that spatial limitations in journals may play a role in what is revealed, and that data reporting standards have evolved since that could make findings Their current status is less applicable to newer drugs.
Rohan Khera, a cardiologist at UT Southwestern Medical Center who has studied the effectiveness of various weight-loss drugs, calls the new analysis “a good start to understanding that this needs to be studied.” study in more detail.”
Dr Sidney Wolfe, a consumer advocate for Public Citizen who has unsuccessfully petitioned US regulators to remove orlistat from the market, believes the risks are high. “If you are a doctor and you rely on medical journals, you can be fooled. Doctors don’t have time to go and read the actual raw data,” he said.
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Damian Garde Biotech Ready for a ‘bio electric vehicle’: Three biotech trends to watch for in 2023 This article will look at the safety of laxatives and whether they can really help you. lose weight or not.
Laxatives are medicines that people use to help stimulate bowel movements or soften stools for easier passage.
They have also become a popular method for weight loss. Many people believe that using laxatives can help increase the frequency of bowel movements and allow for quick, easy, and effortless weight loss.
However, the truth about their safety and effectiveness is a different story, which you will see later in this article.
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There are several different types of laxatives that work in different ways. The main types are (
Bottom Line: Laxatives help stimulate bowel movements. They are a remedy for constipation as well as a popular tool for weight loss. Different types of laxatives help stimulate bowel movements in different ways.
The use of laxatives has become extremely popular among people who want to lose a few pounds quickly. In fact, some studies estimate that more than 4% of the general population abuses laxatives (
Some laxatives work by drawing water from your body into the intestines, allowing the stool to absorb more water to pass more easily. With this method, the only weight you lose is from the amount of water you remove from the stool (
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One small study measured the daily food intake and eating habits of 30 patients with bulimia, an eating disorder that involves eating large amounts of food and then using methods such as: induce vomiting or use laxatives to prevent weight gain.
Compared with other methods used by these patients, the researchers found that using laxatives was an ineffective method for controlling body weight (
Another study also concluded that laxatives were not effective for weight control, noting that laxative use was more common in overweight and obese adolescents than in those of normal weight. often (
To date, there have been no studies to support the idea that laxative use can lead to long-term weight loss.
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Summary: Using laxatives can lead to temporary dehydration. However, studies suggest that this is not an effective method for long-term weight loss.
This is because many laxatives work by drawing water into the intestines from other tissues, resulting in water loss from the stool (
Summary: Some laxatives work by drawing water into the intestines and stools, leading to dehydration and potentially dangerous dehydration.
Electrolytes are substances dissolved in your body fluids that are important in helping your cells and tissues function properly (
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If the balance of these essential electrolytes is lost, it can cause dangerous side effects including seizures, confusion, and coma.
Laxatives can lead to a loss of important electrolytes. This can create an electrolyte imbalance, one of the most dangerous side effects of laxative abuse (
A small study of 24 patients found that laxative use resulted in significant changes in participants’ sodium and potassium levels (
Another study in 2,270 people found that laxatives commonly used in preparation for colonoscopy increased the risk of electrolyte disturbances (
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Summary: Using laxatives can change the electrolyte balance in the body and can cause many
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